Responsible: |
Bodo Erdmann, Jens Lang, Martin Seebass |

Cooperation: |
J. Gellermann, P. Wust,
Rudolf-Virchow-Hospital, Berlin |

Literature: |
B. Erdmann, J. Lang, M. Seebass, Adaptive Solutions of Nonlinear Parabolic
Equations with Application to Hyperthermia Treatments, in Graham
de Vahl Davis, Eddie Leonardi (eds.), CHT'97: Advances in Computational
Heat Transfer, Proc. Int. Symp. on Advances in Comp. Heat Transfer (1997),
pp. 103-110.
B. Erdmann, J. Lang, M. Seebass, Optimization of Temperature Distributions for Regional Hyperthermia based on a Nonlinear Heat Transfer Model, in Ken Diller (ed.), Biotransport: Heat and Mass Transfer in Living Systems, Annals of the New York Academy of Sciences, Vol. 858 (1998), pp. 36-46. J. Lang, B. Erdmann, M. Seebass, The Impact of a Nonlinear Heat Transfer Model for Temperature Control in Regional Hyperthermia, IEEE Transactions on Biomedical Engineering, Vol. 46, No. 9 (1999), pp. 1129-1138. |

Links: |
This activity is part of the development of an medical planning system for regional hyperthermia therapy |

Hyperthermia, i.e., heating tissue to 42

Patient model (torso) and hyperthermia applicator. The patient is surrounded by eight antennas emitting radio waves. A water-filled bolus is placed between patient and antennas.

Studies that predict temperatures in tissue models usually assume a constant-rate blood perfusion within each tissue. However, several experiments have shown that the response of vasculature in tissues to heat stress is strongly temperature-dependent (Song et al., 1984). So the main intention of this work was to develop new nonlinear heat transfer models in order to reflect this important observation, see Figure 2.

There are significant qualitative differences between the temperature distribution predicted by the standard (linear) and the nonlinear heat transfer model. Generally, the self-regulation of healthy tissue is better reflected by the nonlinear model which is now used in practical computations.

Last update: July 2007

© 2007 by Konrad-Zuse-Zentrum für Informationstechnik Berlin (ZIB)