Nonlinear Modelling of Heat Transfer in Regional Hyperthermia

Responsible: Jens Lang, Bodo Erdmann, Martin Seebass
Cooperation: J. Gellermann, P. Wust,
Rudolf-Virchow-Hospital, Berlin
  • B. Erdmann, J. Lang, M. Seebass, Adaptive Solutions of Nonlinear Parabolic Equations with Application to Hyperthermia Treatments,  in Graham de Vahl Davis, Eddie Leonardi (eds.), CHT'97: Advances in Computational Heat Transfer, Proc. Int. Symp. on Advances in Comp. Heat Transfer (1997), pp. 103-110.

  • B. Erdmann, J. Lang, M. Seebass, Optimization of Temperature Distributions for Regional Hyperthermia based on a Nonlinear Heat Transfer Model, in Ken Diller (ed.), Biotransport: Heat and Mass Transfer in Living Systems, Annals of the New York Academy of Sciences, Vol. 858 (1998), pp. 36-46.

  • J. Lang, B. Erdmann, M. Seebass, The Impact of a Nonlinear Heat Transfer Model for Temperature Control in Regional Hyperthermia,  IEEE Transactions on Biomedical Engineering, Vol. 46, No. 9 (1999), pp. 1129-1138.
  • Links: This activity is part of the development of an medical planning system for regional hyperthermia therapy


    Hyperthermia, i.e., heating tissue to 42 oC, is a method of cancer therapy. It is normally applied as an additive therapy to enhance the effect of conventional radio- or chemotherapy. The standard way to produce local heating in the human body is the use of electromagnetic waves. We are mainly interested in regional hyperthermia of deep-seated tumors. For this type of tretment usually a pased array of antennas surrounding the patient is used, see Figure 1. The distribution of absorbed power within the patient's body can be steered by selecting the amplitudes and phases of the antennas' driving voltages. The space between the body and the antennas is filled by a so-called water bolus to avoid excessive heating of the skin.

    Patient model (torso) and hyperthermia applicator. The patient is surrounded by eight antennas emitting radio waves. A water-filled bolus is placed between patient and antennas.

    Optimized Temperature Distribution

    Optimized Temperature Distribution

    Optimized Temperature Distribution

    Last updated 9.10.2000 by Bodo Erdmann